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mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4
Loss of innervation of skeletal muscle is a determinant event in several muscle diseases. Although several effectors have been identified, the pathways controlling the integrated muscle response to denervation remain largely unknown. Here, we demonstrate that PKB/Akt and mTORC1 play important roles...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639401/ https://www.ncbi.nlm.nih.gov/pubmed/31320633 http://dx.doi.org/10.1038/s41467-019-11227-4 |