mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4

Loss of innervation of skeletal muscle is a determinant event in several muscle diseases. Although several effectors have been identified, the pathways controlling the integrated muscle response to denervation remain largely unknown. Here, we demonstrate that PKB/Akt and mTORC1 play important roles...

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Detalles Bibliográficos
Autores principales: Castets, Perrine, Rion, Nathalie, Théodore, Marine, Falcetta, Denis, Lin, Shuo, Reischl, Markus, Wild, Franziska, Guérard, Laurent, Eickhorst, Christopher, Brockhoff, Marielle, Guridi, Maitea, Ibebunjo, Chikwendu, Cruz, Joseph, Sinnreich, Michael, Rudolf, Rüdiger, Glass, David J., Rüegg, Markus A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639401/
https://www.ncbi.nlm.nih.gov/pubmed/31320633
http://dx.doi.org/10.1038/s41467-019-11227-4

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