MEK inhibition drives anti-viral defence in RV but not RSV challenged human airway epithelial cells through AKT/p70S6K/4E-BP1 signalling

BACKGROUND: The airway epithelium is a major target tissue in respiratory infections, and its antiviral response is mainly orchestrated by the interferon regulatory factor-3 (IRF3), which subsequently induces type I (β) and III (λ) interferon (IFN) signalling. Dual specificity mitogen-activated prot...

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Detalles Bibliográficos
Autores principales: Baturcam, Engin, Vollmer, Stefan, Schlüter, Holger, Maciewicz, Rose A., Kurian, Nisha, Vaarala, Outi, Ludwig, Stephan, Cunoosamy, Danen Mootoosamy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639958/
https://www.ncbi.nlm.nih.gov/pubmed/31319869
http://dx.doi.org/10.1186/s12964-019-0378-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639958/
https://www.ncbi.nlm.nih.gov/pubmed/31319869
http://dx.doi.org/10.1186/s12964-019-0378-7

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