Prostaglandin E(2) Signals Through E Prostanoid Receptor 2 to Inhibit Mitochondrial Superoxide Formation and the Ensuing Downstream Cytotoxic and Genotoxic Effects Induced by Arsenite

We investigated the effects of prostaglandin E(2) (PGE(2)), an important inflammatory lipid mediator, on the cytotoxicity–genotoxicity induced by arsenite. With the use of a toxicity paradigm in which the metalloid uniquely induces mitochondrial superoxide (mitoO(2) (−.)) formation, PGE(2) promoted...

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Detalles Bibliográficos
Autores principales: Cerioni, Liana, Guidarelli, Andrea, Fiorani, Mara, Cantoni, Orazio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640088/
https://www.ncbi.nlm.nih.gov/pubmed/31354495
http://dx.doi.org/10.3389/fphar.2019.00781

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640088/
https://www.ncbi.nlm.nih.gov/pubmed/31354495
http://dx.doi.org/10.3389/fphar.2019.00781

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