Cargando…

Prostaglandin E(2) Signals Through E Prostanoid Receptor 2 to Inhibit Mitochondrial Superoxide Formation and the Ensuing Downstream Cytotoxic and Genotoxic Effects Induced by Arsenite

We investigated the effects of prostaglandin E(2) (PGE(2)), an important inflammatory lipid mediator, on the cytotoxicity–genotoxicity induced by arsenite. With the use of a toxicity paradigm in which the metalloid uniquely induces mitochondrial superoxide (mitoO(2) (−.)) formation, PGE(2) promoted...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cerioni, Liana, Guidarelli, Andrea, Fiorani, Mara, Cantoni, Orazio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640088/ https://www.ncbi.nlm.nih.gov/pubmed/31354495 http://dx.doi.org/10.3389/fphar.2019.00781

Ejemplares similares

Calcium signals between the ryanodine receptor- and mitochondria critically regulate the effects of arsenite on mitochondrial superoxide formation and on the ensuing survival vs apoptotic signaling
por: Guidarelli, Andrea, et al.
Publicado: (2018)

Intramitochondrial Ascorbic Acid Enhances the Formation of Mitochondrial Superoxide Induced by Peroxynitrite via a Ca(2+)-Independent Mechanism
por: Guidarelli, Andrea, et al.
Publicado: (2017)

Mitochondrial ROS, ER Stress, and Nrf2 Crosstalk in the Regulation of Mitochondrial Apoptosis Induced by Arsenite
por: Cantoni, Orazio, et al.
Publicado: (2022)

Differentiation of Promonocytic U937 Cells to Monocytes Is Associated with Reduced Mitochondrial Transport of Ascorbic Acid
por: Scotti, Maddalena, et al.
Publicado: (2018)

Cell signaling and cytotoxicity by peroxynitrite.
por: Cantoni, Orazio, et al.
Publicado: (2002)

Activity of the cyclooxygenase 2-prostaglandin-E prostanoid receptor pathway in mice exposed to house dust mite aeroallergens, and impact of exogenous prostaglandin E(2)
por: Herrerias, Aida, et al.
Publicado: (2009)

Prostaglandin E2 Induces Skin Aging via E-Prostanoid 1 in Normal Human Dermal Fibroblasts
por: Shim, Joong Hyun
Publicado: (2019)

Role of the prostaglandin E2/E-prostanoid 2 receptor signalling pathway in TGFβ-induced mice mesangial cell damage
por: Li, Na-Na, et al.
Publicado: (2014)

Expression of prostaglandin E(2) prostanoid receptor EP2 and interleukin-1β in laryngeal carcinoma – preliminary study
por: Mochocki, Marcin, et al.
Publicado: (2015)

Prostaglandin E(2) Prevents Hyperosmolar-Induced Human Mast Cell Activation through Prostanoid Receptors EP(2) and EP(4)
por: Torres-Atencio, Ivonne, et al.
Publicado: (2014)

Prostaglandin E(2) Inhibits Group 2 Innate Lymphoid Cell Activation and Allergic Airway Inflammation Through E-Prostanoid 4-Cyclic Adenosine Monophosphate Signaling
por: Zhou, Yu, et al.
Publicado: (2018)

Temporal correlation of morphological and biochemical changes with the recruitment of different mechanisms of reactive oxygen species formation during human SW872 cell adipogenic differentiation
por: Fiorani, Mara, et al.
Publicado: (2021)

The pharmacological effect of BGC20-1531, a novel prostanoid EP(4) receptor antagonist, in the Prostaglandin E(2) human model of headache
por: Antonova, Maria, et al.
Publicado: (2011)

Clozapine suppresses NADPH oxidase activation, counteracts cytosolic H(2)O(2), and triggers early onset mitochondrial dysfunction during adipogenesis of human liposarcoma SW872 cells
por: Blandino, Giulia, et al.
Publicado: (2023)

Contribution of prostanoid FP receptor and prostaglandins in transient inflammatory ocular hypertension
por: Yamagishi-Kimura, Reiko, et al.
Publicado: (2018)

Role of E-type prostaglandin receptor EP3 in the vasoconstrictor activity evoked by prostacyclin in thromboxane-prostanoid receptor deficient mice
por: Li, Zhenhua, et al.
Publicado: (2017)

Complex Role for E‐Prostanoid 4 Receptors in Hypertension
por: Herrera, Marcela, et al.
Publicado: (2019)

Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E(2)
por: Sampey, Annaleise V, et al.
Publicado: (2005)

Cell‐Specific Actions of the Prostaglandin E‐Prostanoid Receptor 4 Attenuating Hypertension: A Dominant Role for Kidney Epithelial Cells Compared With Macrophages
por: Yang, Ting, et al.
Publicado: (2022)

Differential expression of E-type prostanoid receptors 2 and 4 in microglia stimulated with lipopolysaccharide
por: Bonfill-Teixidor, Ester, et al.
Publicado: (2017)

Niacin ameliorates ulcerative colitis via prostaglandin D(2)‐mediated D prostanoid receptor 1 activation
por: Li, Juanjuan, et al.
Publicado: (2017)

Enhancement of prostaglandin D(2)-D prostanoid 1 signaling reduces intestinal permeability by stimulating mucus secretion
por: Hayashi, Akane, et al.
Publicado: (2023)

Sulforaphane Inhibits Prostaglandin E2 Synthesis by Suppressing Microsomal Prostaglandin E Synthase 1
por: Zhou, Jiping, et al.
Publicado: (2012)

Upregulation of prostaglandin E(2) by inducible microsomal prostaglandin E synthase-1 in colon cancer
por: Kim, Young Hun, et al.
Publicado: (2022)

E-type prostanoid receptor 4 (EP4) in disease and therapy
por: Konya, Viktoria, et al.
Publicado: (2013)

Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming
por: Muraoka, Naoto, et al.
Publicado: (2019)

Protective effects of Vernonia amygdalina against sodium arsenite-induced genotoxicity in rat
por: Adetutu, Adewale, et al.
Publicado: (2013)

Application of a dye-based mitochondrion-thermometry to determine the receptor downstream of prostaglandin E(2) involved in the regulation of hepatocyte metabolism
por: Shen, Lei, et al.
Publicado: (2018)

Prostaglandin E(2) and T cells: friends or foes?
por: Sreeramkumar, Vinatha, et al.
Publicado: (2012)

The ins and outs of prostaglandin E2 in fever
por: Schuster, Victor L
Publicado: (2015)

Up-regulation of cytosolic prostaglandin E synthase in fetal-membrane and amniotic prostaglandin E(2) accumulation in labor
por: Takahashi, Nanase, et al.
Publicado: (2021)

An Oxidoreductase AioE is Responsible for Bacterial Arsenite Oxidation and Resistance
por: Wang, Qian, et al.
Publicado: (2017)

Supplementation with sesame oil suppresses genotoxicity, hepatotoxicity and enterotoxicity induced by sodium arsenite in rats
por: Akinrinde, Akinleye Stephen, et al.
Publicado: (2023)

Is prostaglandin E2 involved in the pathogenesis of fever? Effects of interleukin-1 on the release of prostaglandins.
por: Bernheim, H. A.
Publicado: (1986)

Physiology and pathophysiology of cyclooxygenase-2 and prostaglandin E2 in the kidney
por: Nørregaard, Rikke, et al.
Publicado: (2015)

Induction of Apoptosis in Thymocytes by Prostaglandin E(2) In Vivo
por: Mastino, Antonio, et al.
Publicado: (1992)

Prostaglandin E2 and fever: a continuing debate.
por: Coceani, F., et al.
Publicado: (1986)

Prostaglandin E inhibits the production of human interleukin 2
Publicado: (1982)

The Remarkable Mechanism of Prostaglandin E(2) on Synaptic Plasticity
por: Akaneya, Yukio
Publicado: (2008)

Prostaglandin E(2) As a Modulator of Viral Infections
por: Sander, Willem J., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_3abj82euug0mb992juhfbfri3a