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Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signaling
Cytosolic DNA triggers innate immune responses through activation of cyclic GMP–AMP synthase (cGAS) and production of the cyclic dinucleotide second messenger 2′3′ cGAMP(1–4). 2′3′ cGAMP is a potent inducer of immune signaling, but no intracellular nucleases are known to cleave 2′3′ cGAMP and preven...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640140/ https://www.ncbi.nlm.nih.gov/pubmed/30728498 http://dx.doi.org/10.1038/s41586-019-0928-6 |