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Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signaling

Cytosolic DNA triggers innate immune responses through activation of cyclic GMP–AMP synthase (cGAS) and production of the cyclic dinucleotide second messenger 2′3′ cGAMP(1–4). 2′3′ cGAMP is a potent inducer of immune signaling, but no intracellular nucleases are known to cleave 2′3′ cGAMP and preven...

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Detalles Bibliográficos
Autores principales: Eaglesham, James B., Pan, Youdong, Kupper, Thomas S., Kranzusch, Philip J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640140/
https://www.ncbi.nlm.nih.gov/pubmed/30728498
http://dx.doi.org/10.1038/s41586-019-0928-6