Tuning Relative Polypeptide Expression to Optimize Assembly, Yield and Downstream Processing of Bispecific Antibodies

Bispecific antibodies (bsAbs) are often composed of several polypeptide chains that have to be expressed adequately to enable optimal assembly and yield of the bsAb. κλ bodies are a bispecific format with a native IgG structure, composed of two different light chains that pair with a common heavy ch...

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Detalles Bibliográficos
Autores principales: Magistrelli, Giovanni, Pontini, Guillemette, Poitevin, Yves, Malinge, Pauline, Bourguignon, Jérémie, Gauye, Florence, Fleury, Elise, Plèche, Nicolas, Galissaires, Lydia, Fischer, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640677/
https://www.ncbi.nlm.nih.gov/pubmed/31544881
http://dx.doi.org/10.3390/antib7030029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640677/
https://www.ncbi.nlm.nih.gov/pubmed/31544881
http://dx.doi.org/10.3390/antib7030029

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