Relative Contribution of Framework and CDR Regions in Antibody Variable Domains to Multimerisation of Fv- and scFv-Containing Bispecific Antibodies

Bispecific antibodies represent an emerging class of antibody drugs that are commonly generated by fusion of Fv or scFv antigen binding domains to IgG or Fab scaffolds. Fv- or scFv-mediated multimerisation of bispecific antibodies via promiscuous vH-vL pairing can result in sub-optimal monomer level...

Descripción completa

Detalles Bibliográficos
Autores principales: Bhatta, Pallavi, Humphreys, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640685/
https://www.ncbi.nlm.nih.gov/pubmed/31544885
http://dx.doi.org/10.3390/antib7030035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640685/
https://www.ncbi.nlm.nih.gov/pubmed/31544885
http://dx.doi.org/10.3390/antib7030035

Ejemplares similares