Super Potent Bispecific Llama VHH Antibodies Neutralize HIV via a Combination of gp41 and gp120 Epitopes

Broad and potent neutralizing llama single domain antibodies (VHH) against HIV-1 targeting the CD4 binding site (CD4bs) have previously been isolated upon llama immunization. Here we describe the epitopes of three additional VHH groups selected from phage libraries. The 2E7 group binds to a new line...

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Detalles Bibliográficos
Autores principales: Strokappe, Nika M., Hock, Miriam, Rutten, Lucy, Mccoy, Laura E., Back, Jaap W., Caillat, Christophe, Haffke, Matthias, Weiss, Robin A., Weissenhorn, Winfried, Verrips, Theo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640723/
https://www.ncbi.nlm.nih.gov/pubmed/31544844
http://dx.doi.org/10.3390/antib8020038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640723/
https://www.ncbi.nlm.nih.gov/pubmed/31544844
http://dx.doi.org/10.3390/antib8020038

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