Isomeric Replacement of a Single Aspartic Acid Induces a Marked Change in Protein Function: The Example of Ribonuclease A

[Image: see text] lα-Aspartic acid (Asp) residues in proteins are nonenzymatically isomerized to abnormal lβ-, dα-, and dβ-Asp isomers under physiological conditions. Such an isomerization of Asp residues is considered to be a trigger of protein denaturation because it either elongates the main chai...

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Detalles Bibliográficos
Autores principales: Sakaue, Hiroaki, Kinouchi, Tadatoshi, Fujii, Norihiko, Takata, Takumi, Fujii, Noriko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641078/
https://www.ncbi.nlm.nih.gov/pubmed/31457226
http://dx.doi.org/10.1021/acsomega.6b00346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641078/
https://www.ncbi.nlm.nih.gov/pubmed/31457226
http://dx.doi.org/10.1021/acsomega.6b00346

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