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One-Pot Tandem Hiyama Alkynylation/Cyclizations by Palladium(II) Acyclic Diaminocarbene (ADC) Complexes Yielding Biologically Relevant Benzofuran Scaffolds
[Image: see text] A series of palladium acyclic diaminocarbene (ADC) complexes of the type cis-[(R(1)NH)(R(2))methylidene]PdCl(2)(CNR(1)) [R(1) = 2,4,6-(CH(3))(3)C(6)H(2): R(2) = NC(5)H(10) (2); NC(4)H(8) (3); NC(4)H(8)O (4)] were used not only to perform the C(sp(2))–C(sp) Hiyama coupling between a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641338/ https://www.ncbi.nlm.nih.gov/pubmed/31458491 http://dx.doi.org/10.1021/acsomega.7b01974 |
Sumario: | [Image: see text] A series of palladium acyclic diaminocarbene (ADC) complexes of the type cis-[(R(1)NH)(R(2))methylidene]PdCl(2)(CNR(1)) [R(1) = 2,4,6-(CH(3))(3)C(6)H(2): R(2) = NC(5)H(10) (2); NC(4)H(8) (3); NC(4)H(8)O (4)] were used not only to perform the C(sp(2))–C(sp) Hiyama coupling between aryl iodide and triethoxysilylalkynes but also to subsequently carry out the one-pot tandem Hiyama alkynylation/cyclization reaction between 2-iodophenol and triethoxysilylalkynes, giving a convenient time-efficient access to the biologically relevant benzofuran compounds. The palladium ADC complexes (2–4) were conveniently synthesized by the nucleophilic addition of secondary amines, namely, piperidine, pyrrolidine, and morpholine on the cis-{(2,4,6-(CH(3))(3)C(6)H(2))NC}(2)PdCl(2) in moderate yields (ca. 61–66%). |
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