Synthesis of Asthma Drug Zafirlukast (Accolate) Using Intramolecular Oxidative Coupling via sp(3) C–H Bond Activation

[Image: see text] The FDA-approved drug for the treatment of asthma, zafirlukast, is synthesized engaging multiple catalytic reactions including a new method for the construction of 3-aroylindoles via oxidative cyclization. The highlights include transition-metal and peroxide free C–H bond activatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Paladugu, Srinu, Mainkar, Prathama S., Chandrasekhar, Srivari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641481/
https://www.ncbi.nlm.nih.gov/pubmed/31458657
http://dx.doi.org/10.1021/acsomega.8b00476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641481/
https://www.ncbi.nlm.nih.gov/pubmed/31458657
http://dx.doi.org/10.1021/acsomega.8b00476

Ejemplares similares