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Synthesis of Asthma Drug Zafirlukast (Accolate) Using Intramolecular Oxidative Coupling via sp(3) C–H Bond Activation

[Image: see text] The FDA-approved drug for the treatment of asthma, zafirlukast, is synthesized engaging multiple catalytic reactions including a new method for the construction of 3-aroylindoles via oxidative cyclization. The highlights include transition-metal and peroxide free C–H bond activatio...

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Detalles Bibliográficos
Autores principales:	Paladugu, Srinu, Mainkar, Prathama S., Chandrasekhar, Srivari
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641481/ https://www.ncbi.nlm.nih.gov/pubmed/31458657 http://dx.doi.org/10.1021/acsomega.8b00476

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