Gram-Scale Laboratory Synthesis of TC AC 28, a High-Affinity BET Bromodomain Ligand

[Image: see text] TC AC 28, 6-(1H-Indol-4-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetic acid methyl ester, has been synthesized on a near-gram scale in seven steps with notable improvements in the reported poor-yielding last two steps enabling this key chemical probe c...

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Detalles Bibliográficos
Autores principales: Khan, Raysa, Marsh, Graham, Felix, Robert, Kemmitt, Paul D., Baud, Matthias G. J., Ciulli, Alessio, Spencer, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641879/
https://www.ncbi.nlm.nih.gov/pubmed/31457724
http://dx.doi.org/10.1021/acsomega.7b00780

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641879/
https://www.ncbi.nlm.nih.gov/pubmed/31457724
http://dx.doi.org/10.1021/acsomega.7b00780

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