Gram-Scale Laboratory Synthesis of TC AC 28, a High-Affinity BET Bromodomain Ligand

[Image: see text] TC AC 28, 6-(1H-Indol-4-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetic acid methyl ester, has been synthesized on a near-gram scale in seven steps with notable improvements in the reported poor-yielding last two steps enabling this key chemical probe c...

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Autores principales: Khan, Raysa, Marsh, Graham, Felix, Robert, Kemmitt, Paul D., Baud, Matthias G. J., Ciulli, Alessio, Spencer, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641879/
https://www.ncbi.nlm.nih.gov/pubmed/31457724
http://dx.doi.org/10.1021/acsomega.7b00780
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author Khan, Raysa
Marsh, Graham
Felix, Robert
Kemmitt, Paul D.
Baud, Matthias G. J.
Ciulli, Alessio
Spencer, John
author_facet Khan, Raysa
Marsh, Graham
Felix, Robert
Kemmitt, Paul D.
Baud, Matthias G. J.
Ciulli, Alessio
Spencer, John
author_sort Khan, Raysa
collection PubMed
description [Image: see text] TC AC 28, 6-(1H-Indol-4-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetic acid methyl ester, has been synthesized on a near-gram scale in seven steps with notable improvements in the reported poor-yielding last two steps enabling this key chemical probe compound to be available for researchers.
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spelling pubmed-66418792019-08-27 Gram-Scale Laboratory Synthesis of TC AC 28, a High-Affinity BET Bromodomain Ligand Khan, Raysa Marsh, Graham Felix, Robert Kemmitt, Paul D. Baud, Matthias G. J. Ciulli, Alessio Spencer, John ACS Omega [Image: see text] TC AC 28, 6-(1H-Indol-4-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetic acid methyl ester, has been synthesized on a near-gram scale in seven steps with notable improvements in the reported poor-yielding last two steps enabling this key chemical probe compound to be available for researchers. American Chemical Society 2017-08-08 /pmc/articles/PMC6641879/ /pubmed/31457724 http://dx.doi.org/10.1021/acsomega.7b00780 Text en Copyright © 2017 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Khan, Raysa
Marsh, Graham
Felix, Robert
Kemmitt, Paul D.
Baud, Matthias G. J.
Ciulli, Alessio
Spencer, John
Gram-Scale Laboratory Synthesis of TC AC 28, a High-Affinity BET Bromodomain Ligand
title Gram-Scale Laboratory Synthesis of TC AC 28, a High-Affinity BET Bromodomain Ligand
title_full Gram-Scale Laboratory Synthesis of TC AC 28, a High-Affinity BET Bromodomain Ligand
title_fullStr Gram-Scale Laboratory Synthesis of TC AC 28, a High-Affinity BET Bromodomain Ligand
title_full_unstemmed Gram-Scale Laboratory Synthesis of TC AC 28, a High-Affinity BET Bromodomain Ligand
title_short Gram-Scale Laboratory Synthesis of TC AC 28, a High-Affinity BET Bromodomain Ligand
title_sort gram-scale laboratory synthesis of tc ac 28, a high-affinity bet bromodomain ligand
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641879/
https://www.ncbi.nlm.nih.gov/pubmed/31457724
http://dx.doi.org/10.1021/acsomega.7b00780
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