Cargando…
Gram-Scale Laboratory Synthesis of TC AC 28, a High-Affinity BET Bromodomain Ligand
[Image: see text] TC AC 28, 6-(1H-Indol-4-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetic acid methyl ester, has been synthesized on a near-gram scale in seven steps with notable improvements in the reported poor-yielding last two steps enabling this key chemical probe c...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2017
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641879/ https://www.ncbi.nlm.nih.gov/pubmed/31457724 http://dx.doi.org/10.1021/acsomega.7b00780 |