Chemo-Enzymatic Synthesis, Structural and Stereochemical Characterization, and Intrinsic Degradation Kinetics of Diastereomers of 1-β-O-Acyl Glucuronides Derived from Racemic 2-{4-[(2-Methylprop-2-en-1-yl)amino]phenyl}propanoic Acid

[Image: see text] Alminoprofen, (RS)-2-{4-[(2-methylprop-2-en-1-yl)amino]phenyl}propanoic acid (ALP) 1, is a racemic drug categorized as a 2-arylpropanoic acid-class nonsteroidal anti-inflammatory drug. Pharmacokinetic studies of 1 in patients have revealed that the corresponding acyl glucuronide 5...

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Detalles Bibliográficos
Autores principales: Baba, Akiko, Yamada, Koki, Satoh, Takashi, Watanabe, Kazuhiro, Yoshioka, Tadao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641924/
https://www.ncbi.nlm.nih.gov/pubmed/31458709
http://dx.doi.org/10.1021/acsomega.8b00443

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641924/
https://www.ncbi.nlm.nih.gov/pubmed/31458709
http://dx.doi.org/10.1021/acsomega.8b00443

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