Covalent Targeting of the Vacuolar H(+)-ATPase Activates Autophagy Via mTORC1 Inhibition

Autophagy is a lysosomal degradation pathway that eliminates aggregated proteins and damaged organelles to maintain cellular homeostasis. A major route for activating autophagy involves inhibition of the mTORC1 kinase, but current mTORC1-targeting compounds do not allow complete and selective mTORC1...

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Detalles Bibliográficos
Autores principales: Yik-Sham Chung, Clive, Shin, Hijai R., Berdan, Charles A., Ford, Breanna, Ward, Carl C., Olzmann, James A., Zoncu, Roberto, Nomura, Daniel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641988/
https://www.ncbi.nlm.nih.gov/pubmed/31285595
http://dx.doi.org/10.1038/s41589-019-0308-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641988/
https://www.ncbi.nlm.nih.gov/pubmed/31285595
http://dx.doi.org/10.1038/s41589-019-0308-4

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