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Covalent Targeting of the Vacuolar H(+)-ATPase Activates Autophagy Via mTORC1 Inhibition

Autophagy is a lysosomal degradation pathway that eliminates aggregated proteins and damaged organelles to maintain cellular homeostasis. A major route for activating autophagy involves inhibition of the mTORC1 kinase, but current mTORC1-targeting compounds do not allow complete and selective mTORC1...

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Detalles Bibliográficos
Autores principales:	Yik-Sham Chung, Clive, Shin, Hijai R., Berdan, Charles A., Ford, Breanna, Ward, Carl C., Olzmann, James A., Zoncu, Roberto, Nomura, Daniel K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641988/ https://www.ncbi.nlm.nih.gov/pubmed/31285595 http://dx.doi.org/10.1038/s41589-019-0308-4

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