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Stochastic search and joint fine-mapping increases accuracy and identifies previously unreported associations in immune-mediated diseases
Thousands of genetic variants are associated with human disease risk, but linkage disequilibrium (LD) hinders fine-mapping the causal variants. Both lack of power, and joint tagging of two or more distinct causal variants by a single non-causal SNP, lead to inaccuracies in fine-mapping, with stochas...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642100/ https://www.ncbi.nlm.nih.gov/pubmed/31324808 http://dx.doi.org/10.1038/s41467-019-11271-0 |