Essential genes shape cancer genomes through linear limitation of homozygous deletions

The landscape of somatic acquired deletions in cancer cells is shaped by positive and negative selection. Recurrent deletions typically target tumor suppressor, leading to positive selection. Simultaneously, loss of a nearby essential gene can lead to negative selection, and introduce latent vulnera...

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Detalles Bibliográficos
Autores principales: Pertesi, Maroulio, Ekdahl, Ludvig, Palm, Angelica, Johnsson, Ellinor, Järvstråt, Linnea, Wihlborg, Anna-Karin, Nilsson, Björn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642121/
https://www.ncbi.nlm.nih.gov/pubmed/31341961
http://dx.doi.org/10.1038/s42003-019-0517-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642121/
https://www.ncbi.nlm.nih.gov/pubmed/31341961
http://dx.doi.org/10.1038/s42003-019-0517-0

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