Hyperglycemia exacerbates acetaminophen-induced acute liver injury by promoting liver-resident macrophage proinflammatory response via AMPK/PI3K/AKT-mediated oxidative stress

Although diabetes mellitus/hyperglycemia is a risk factor for acute liver injury, the underlying mechanism remains largely unknown. Liver-resident macrophages (Kupffer cells, KCs) and oxidative stress play critical roles in the pathogenesis of toxin-induced liver injury. Here, we evaluated the role...

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Detalles Bibliográficos
Autores principales: Wang, Qi, Wei, Song, Zhou, Haoming, Shen, Gefenqiang, Gan, Xiaojie, Zhou, Shun, Qiu, Jiannan, Shi, Chenyu, Lu, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642179/
https://www.ncbi.nlm.nih.gov/pubmed/31341645
http://dx.doi.org/10.1038/s41420-019-0198-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642179/
https://www.ncbi.nlm.nih.gov/pubmed/31341645
http://dx.doi.org/10.1038/s41420-019-0198-y

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