Molecular mechanism of setron-mediated inhibition of full-length 5-HT(3A) receptor

Serotonin receptor (5-HT(3A)R) is the most common therapeutic target to manage the nausea and vomiting during cancer therapies and in the treatment of irritable bowel syndrome. Setrons, a class of competitive antagonists, cause functional inhibition of 5-HT(3A)R in the gastrointestinal tract and bra...

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Detalles Bibliográficos
Autores principales: Basak, Sandip, Gicheru, Yvonne, Kapoor, Abhijeet, Mayer, Megan L., Filizola, Marta, Chakrapani, Sudha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642186/
https://www.ncbi.nlm.nih.gov/pubmed/31324772
http://dx.doi.org/10.1038/s41467-019-11142-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642186/
https://www.ncbi.nlm.nih.gov/pubmed/31324772
http://dx.doi.org/10.1038/s41467-019-11142-8

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