Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response

MAVS is essential for antiviral immunity, but the molecular mechanisms responsible for its tight regulation remain poorly understood. Here, we show that NLK inhibits the antiviral immune response during viral infection by targeting MAVS for degradation. NLK depletion promotes virus-induced antiviral...

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Detalles Bibliográficos
Autores principales: Li, Shang-Ze, Shu, Qi-Peng, Song, Yang, Zhang, Hui-Hui, Liu, Yi, Jin, Bing-Xue, Liuyu, Tian-Zi, Li, Chao, Huang, Xi-Chen, Du, Run-Lei, Song, Wei, Zhong, Bo, Zhang, Xiao-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642205/
https://www.ncbi.nlm.nih.gov/pubmed/31324787
http://dx.doi.org/10.1038/s41467-019-11258-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642205/
https://www.ncbi.nlm.nih.gov/pubmed/31324787
http://dx.doi.org/10.1038/s41467-019-11258-x

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