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Vitamin D(3)-vitamin D receptor axis suppresses pulmonary emphysema by maintaining alveolar macrophage homeostasis and function

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by emphysema and/or obstructive bronchiolitis. Deficiency in vitamin D(3) (VD3), which regulates gene expression through binding to vitamin D receptor (VDR), is associated with high risks of COPD susceptibility. Alveolar macro...

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Detalles Bibliográficos
Autores principales: Hu, Guangan, Dong, Ting, Wang, Sisi, Jing, Hongyu, Chen, Jianzhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642288/
https://www.ncbi.nlm.nih.gov/pubmed/31278070
http://dx.doi.org/10.1016/j.ebiom.2019.06.039