Cargando…

Genetically-predicted life-long lowering of low-density lipoprotein cholesterol is associated with decreased frailty: A Mendelian randomization study in UK biobank

BACKGROUND: High circulating low-density lipoprotein cholesterol (LDL-C) is a major risk factor for atherosclerosis and age-associated cardiovascular events. Long-term dyslipidaemia could contribute to the development of frailty in older individuals through its role in determining cardiovascular hea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Qi, Wang, Yunzhang, Lehto, Kelli, Pedersen, Nancy L., Williams, Dylan M., Hägg, Sara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642403/ https://www.ncbi.nlm.nih.gov/pubmed/31300347 http://dx.doi.org/10.1016/j.ebiom.2019.07.007

Ejemplares similares

A Frailty Index for UK Biobank Participants
por: Williams, Dylan M, et al.
Publicado: (2019)

Low-density lipoprotein cholesterol and atrial fibrillation; A Mendelian randomization study using UK-Biobank data
por: Katsoulis, Michail, et al.
Publicado: (2017)

Frailty and comorbidity in predicting community COVID‐19 mortality in the U.K. Biobank: The effect of sampling
por: Mak, Jonathan K. L., et al.
Publicado: (2021)

Fatty Acids and Frailty: A Mendelian Randomization Study
por: Tomata, Yasutake, et al.
Publicado: (2021)

Protein Nutritional Status and Frailty: A Mendelian Randomization Study
por: Tomata, Yasutake, et al.
Publicado: (2021)

Association between genetically predicted telomere length and facial skin aging in the UK Biobank: a Mendelian randomization study
por: Zhan, Yiqiang, et al.
Publicado: (2020)

Association of pre-pandemic high-density lipoprotein cholesterol with risk of COVID-19 hospitalisation and death: The UK Biobank cohort study
por: Lassale, Camille, et al.
Publicado: (2021)

Association of pre-pandemic high-density lipoprotein cholesterol with risk of COVID-19 hospitalisation and death: the UK Biobank cohort study
por: Lassale, Camille, et al.
Publicado: (2021)

CAUSES OF FRAILTY: GENETIC ANALYSIS IN 164,000 UK BIOBANK PARTICIPANTS
por: Atkins, Janice, et al.
Publicado: (2019)

Low-density lipoprotein cholesterol and risk of hepatocellular carcinoma: a Mendelian randomization and mediation analysis
por: Cao, Jiali, et al.
Publicado: (2023)

Unraveling the metabolic underpinnings of frailty using multicohort observational and Mendelian randomization analyses
por: Mak, Jonathan K. L., et al.
Publicado: (2023)

Causal relevance of circulating high-density lipoprotein cholesterol with cancer: a Mendelian randomization meta-analysis
por: Yang, Chunhua, et al.
Publicado: (2015)

Triglyceride-glucose index and triglyceride to high-density lipoprotein cholesterol ratio as potential cardiovascular disease risk factors: an analysis of UK biobank data
por: Che, Bizhong, et al.
Publicado: (2023)

Circulating antioxidants and Alzheimer disease prevention: a Mendelian randomization study
por: Williams, Dylan M, et al.
Publicado: (2019)

A genome‐wide association study of the frailty index highlights brain pathways in ageing
por: Atkins, Janice L., et al.
Publicado: (2021)

Triglyceride-rich lipoprotein remnants, low-density lipoproteins, and risk of coronary heart disease: a UK Biobank study
por: Björnson, Elias, et al.
Publicado: (2023)

Effects of general and central adiposity on circulating lipoprotein, lipid, and metabolite levels in UK Biobank: A multivariable Mendelian randomization study
por: Bell, Joshua A., et al.
Publicado: (2022)

A 90 minute soccer match decreases triglyceride and low density lipoprotein but not high-density lipoprotein and cholesterol levels
por: Rahnama, Nader, et al.
Publicado: (2009)

Frailty and the risk of dementia: is the association explained by shared environmental and genetic factors?
por: Bai, Ge, et al.
Publicado: (2021)

Comparison of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol and total cholesterol/high-density lipoprotein cholesterol for the prediction of thin-cap fibroatheroma determined by intravascular optical coherence tomography
por: WANG, Yao, et al.
Publicado: (2020)

Cholesteryl ester transfer protein inhibitors: from high-density lipoprotein cholesterol to low-density lipoprotein cholesterol lowering agents?
por: Nurmohamed, Nick S, et al.
Publicado: (2021)

Triglyceride to high‐density lipoprotein cholesterol ratio is associated with incident diabetes in men: A retrospective study of Chinese individuals
por: Qin, Hailun, et al.
Publicado: (2019)

Dapagliflozin decreases small dense low-density lipoprotein-cholesterol and increases high-density lipoprotein 2-cholesterol in patients with type 2 diabetes: comparison with sitagliptin
por: Hayashi, Toshiyuki, et al.
Publicado: (2017)

Decreased high-density lipoprotein cholesterol levels in polyarticular juvenile idiopathic arthritis
por: Marangoni, Roberta Gonçalves, et al.
Publicado: (2011)

Prognostic Value of Decreased High-Density Lipoprotein Cholesterol Levels in Infective Endocarditis
por: Zampino, Rosa, et al.
Publicado: (2022)

Implementing a method for studying longitudinal DNA methylation variability in association with age
por: Wang, Yunzhang, et al.
Publicado: (2018)

Inclisiran, Low-Density Lipoprotein Cholesterol and Lipoprotein (a)
por: Katsiki, Niki, et al.
Publicado: (2023)

Total cholesterol/high-density lipoprotein cholesterol and low-density lipoprotein cholesterol/high-density lipoprotein cholesterol as predictors of coronary artery calcification assessed by multidetector computed tomography coronary angiography
por: Elsadek Seaoud, Elshaimaa Aly M., et al.
Publicado: (2022)

Association of the Low-density Lipoprotein Cholesterol/High-density Lipoprotein Cholesterol Ratio with Glecaprevir-pibrentasvir Treatment
por: Akutsu, Noriyuki, et al.
Publicado: (2021)

Low bone mineral density is associated with gray matter volume decrease in UK Biobank
por: Kalc, Polona, et al.
Publicado: (2023)

Correction to: Dapagliflozin decreases small dense low-density lipoprotein-cholesterol and increases high-density lipoprotein 2-cholesterol in patients with type 2 diabetes: comparison with sitagliptin
por: Hayashi, Toshiyuki, et al.
Publicado: (2017)

Assessment of serum levels of triglycerides, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol in periodontitis patients
por: Penumarthy, Swati, et al.
Publicado: (2013)

Circulating insulin-like growth factors and Alzheimer disease: A mendelian randomization study
por: Williams, Dylan M., et al.
Publicado: (2018)

Role of obesity in smoking behaviour: Mendelian randomisation study in UK Biobank
por: Carreras-Torres, Robert, et al.
Publicado: (2018)

BMI and Mortality in UK Biobank: Revised Estimates Using Mendelian Randomization
por: Wade, Kaitlin H., et al.
Publicado: (2018)

Educational attainment and drinking behaviors: Mendelian randomization study in UK Biobank
por: Zhou, Tao, et al.
Publicado: (2019)

Adiposity and grip strength: a Mendelian randomisation study in UK Biobank
por: Pinto Pereira, Snehal M., et al.
Publicado: (2022)

Falsification of the instrumental variable conditions in Mendelian randomization studies in the UK Biobank
por: Guo, Kelly, et al.
Publicado: (2023)

Low-density lipoprotein cholesterol lowering treatment: the current approach
por: Crismaru, Irina, et al.
Publicado: (2020)

Mendelian Randomization Implicates High-Density Lipoprotein Cholesterol–Associated Mechanisms in Etiology of Age-Related Macular Degeneration
por: Burgess, Stephen, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_368brc43jkfod6htup97gc7t5j