FAM129B, an antioxidative protein, reduces chemosensitivity by competing with Nrf2 for Keap1 binding

BACKGROUND: The transcription factor Nrf2 is a master regulator of antioxidant response. While Nrf2 activation may counter increasing oxidative stress in aging, its activation in cancer can promote cancer progression and metastasis, and confer resistance to chemotherapy and radiotherapy. Thus, Nrf2...

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Detalles Bibliográficos
Autores principales: Cheng, Kai-Chun, Lin, Ruey-Jen, Cheng, Jing-Yan, Wang, Sheng-Hung, Yu, Jyh-Cherng, Wu, Jen-Chine, Liang, Yuh-Jin, Hsu, Huan-Ming, Yu, John, Yu, Alice L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642435/
https://www.ncbi.nlm.nih.gov/pubmed/31262713
http://dx.doi.org/10.1016/j.ebiom.2019.06.022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642435/
https://www.ncbi.nlm.nih.gov/pubmed/31262713
http://dx.doi.org/10.1016/j.ebiom.2019.06.022

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