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FAM129B, an antioxidative protein, reduces chemosensitivity by competing with Nrf2 for Keap1 binding
BACKGROUND: The transcription factor Nrf2 is a master regulator of antioxidant response. While Nrf2 activation may counter increasing oxidative stress in aging, its activation in cancer can promote cancer progression and metastasis, and confer resistance to chemotherapy and radiotherapy. Thus, Nrf2...
Autores principales: | Cheng, Kai-Chun, Lin, Ruey-Jen, Cheng, Jing-Yan, Wang, Sheng-Hung, Yu, Jyh-Cherng, Wu, Jen-Chine, Liang, Yuh-Jin, Hsu, Huan-Ming, Yu, John, Yu, Alice L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642435/ https://www.ncbi.nlm.nih.gov/pubmed/31262713 http://dx.doi.org/10.1016/j.ebiom.2019.06.022 |
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