p53 sensitizes chemoresistant non-small cell lung cancer via elevation of reactive oxygen species and suppression of EGFR/PI3K/AKT signaling

BACKGROUND: Non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths primarily due to chemoresistance. Somatic mutation of TP53 (36%) and epidermal growth factor receptor (EGFR; > 30%) are major contributors to cisplatin (CDDP) resistance. Substantial evidence suggests the elevate...

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Detalles Bibliográficos
Autores principales: Zhang, Yize, Han, Chae Young, Duan, Fu Gang, Fan, Xing-Xing, Yao, Xiao-Jun, Parks, Robin J., Tang, Yi-Jun, Wang, Mei-Fang, Liu, Liang, Tsang, Benjamin K., Leung, Elaine Lai-Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642601/
https://www.ncbi.nlm.nih.gov/pubmed/31360122
http://dx.doi.org/10.1186/s12935-019-0910-2