Cargando…

p53 sensitizes chemoresistant non-small cell lung cancer via elevation of reactive oxygen species and suppression of EGFR/PI3K/AKT signaling

BACKGROUND: Non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths primarily due to chemoresistance. Somatic mutation of TP53 (36%) and epidermal growth factor receptor (EGFR; > 30%) are major contributors to cisplatin (CDDP) resistance. Substantial evidence suggests the elevate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yize, Han, Chae Young, Duan, Fu Gang, Fan, Xing-Xing, Yao, Xiao-Jun, Parks, Robin J., Tang, Yi-Jun, Wang, Mei-Fang, Liu, Liang, Tsang, Benjamin K., Leung, Elaine Lai-Han
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642601/ https://www.ncbi.nlm.nih.gov/pubmed/31360122 http://dx.doi.org/10.1186/s12935-019-0910-2

Ejemplares similares

SCD1 is required for EGFR-targeting cancer therapy of lung cancer via re-activation of EGFR/PI3K/AKT signals
por: She, Kelin, et al.
Publicado: (2019)

Activation of EGFR-PI3K-AKT signaling is required for Mycoplasma hyorhinis-promoted gastric cancer cell migration
por: Duan, Hongying, et al.
Publicado: (2014)

[6]-Paradol suppresses proliferation and metastases of pancreatic cancer by decreasing EGFR and inactivating PI3K/AKT signaling
por: Jiang, Xueyi, et al.
Publicado: (2021)

miR-125a-5p post-transcriptionally suppresses GALNT7 to inhibit proliferation and invasion in cervical cancer cells via the EGFR/PI3K/AKT pathway
por: Cao, Qinxue, et al.
Publicado: (2020)

Uev1A promotes breast cancer cell survival and chemoresistance through the AKT-FOXO1-BIM pathway
por: Wu, Zhaojia, et al.
Publicado: (2019)

The differential susceptibilities of MCF-7 and MDA-MB-231 cells to the cytotoxic effects of curcumin are associated with the PI3K/Akt-SKP2-Cip/Kips pathway
por: Jia, Tao, et al.
Publicado: (2014)

Heat shock protein 27 downstream of P38-PI3K/Akt signaling antagonizes melatonin-induced apoptosis of SGC-7901 gastric cancer cells
por: Deng, Wenjie, et al.
Publicado: (2016)

miR-30b-5p inhibits proliferation, invasion, and migration of papillary thyroid cancer by targeting GALNT7 via the EGFR/PI3K/AKT pathway
por: Wang, Ye, et al.
Publicado: (2021)

Biological indicators of chemoresistance: an ex vivo analysis of γH2AX and p53 expression in feline injection-site sarcomas
por: Bing, Yike, et al.
Publicado: (2018)

Benzimidazoisoquinoline derivatives inhibit glioblastoma cell proliferation through down-regulating Raf/MEK/ERK and PI3K/AKT pathways
por: Zhang, Ya-Jun, et al.
Publicado: (2018)

Extracellular HMGB1 interacts with RAGE and promotes chemoresistance in acute leukemia cells
por: Lai, Weixin, et al.
Publicado: (2021)

ZEB1-AS1/miR-133a-3p/LPAR3/EGFR axis promotes the progression of thyroid cancer by regulating PI3K/AKT/mTOR pathway
por: Xia, Wu, et al.
Publicado: (2020)

Midkine promotes glioblastoma progression via PI3K-Akt signaling
por: Hu, Beiquan, et al.
Publicado: (2021)

miR-125b develops chemoresistance in Ewing sarcoma/primitive neuroectodermal tumor
por: Iida, Keiichiro, et al.
Publicado: (2013)

CMTM3 suppresses chordoma progress through EGFR/STAT3 regulated EMT and TP53 signaling pathway
por: Yuan, Wanqiong, et al.
Publicado: (2021)

Hexokinases 2 promoted cell motility and distant metastasis by elevating fibronectin through Akt1/p-Akt1 in cervical cancer cells
por: Chen, Qian, et al.
Publicado: (2021)

AL355338 acts as an oncogenic lncRNA by interacting with protein ENO1 to regulate EGFR/AKT pathway in NSCLC
por: Hua, Qian, et al.
Publicado: (2021)

Matrine combined with cisplatin synergistically inhibited urothelial bladder cancer cells via down-regulating VEGF/PI3K/Akt signaling pathway
por: Liao, Xiao-Zhong, et al.
Publicado: (2017)

TUFT1 promotes metastasis and chemoresistance in triple negative breast cancer through the TUFT1/Rab5/Rac1 pathway
por: Liu, Weiguang, et al.
Publicado: (2019)

PI3-K/Akt pathway contributes to IL-6-dependent growth of 7TD1 cells
por: Zhang, JiYan, et al.
Publicado: (2003)

Celecoxib enhances anticancer effect of cisplatin and induces anoikis in osteosarcoma via PI3K/Akt pathway
por: Liu, Bing, et al.
Publicado: (2017)

Effect of nicastrin on hepatocellular carcinoma proliferation and apoptosis through PI3K/AKT signalling pathway modulation
por: Wang, Xicheng, et al.
Publicado: (2020)

Periostin promotes the proliferation and metastasis of osteosarcoma by increasing cell survival and activates the PI3K/Akt pathway
por: Xu, Chaojian, et al.
Publicado: (2022)

PGM1 suppresses colorectal cancer cell migration and invasion by regulating the PI3K/AKT pathway
por: Zheng, Zhewen, et al.
Publicado: (2022)

Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K/AKT signaling in ovarian cancer
por: Chan, Karen K. L., et al.
Publicado: (2018)

CMTM5 is downregulated and suppresses tumour growth in hepatocellular carcinoma through regulating PI3K-AKT signalling
por: Xu, Gang, et al.
Publicado: (2017)

SKA3 promotes cell proliferation and migration in cervical cancer by activating the PI3K/Akt signaling pathway
por: Hu, Rong, et al.
Publicado: (2018)

YY1 activates EMI2 and promotes the progression of cholangiocarcinoma through the PI3K/Akt signaling axis
por: Zhou, Shuai, et al.
Publicado: (2021)

Aloperine inhibits the progression of non-small-cell lung cancer through the PI3K/Akt signaling pathway
por: Liu, Fujuan, et al.
Publicado: (2021)

Targeting DNAJC19 overcomes tumor growth and lung metastasis in NSCLC by regulating PI3K/AKT signaling
por: Zhou, Ji, et al.
Publicado: (2021)

JOSD1 promotes proliferation and chemoresistance of head and neck squamous cell carcinoma under the epigenetic regulation of BRD4
por: Jing, Chao, et al.
Publicado: (2021)

Blockade of PI3K/AKT pathway enhances sensitivity of Raji cells to chemotherapy through down-regulation of HSP70
por: Fang, Xiaosheng, et al.
Publicado: (2013)

LPAR1 regulates the development of intratumoral heterogeneity in ovarian serous cystadenocarcinoma by activating the PI3K/AKT signaling pathway
por: Cui, Ran, et al.
Publicado: (2019)

Protopine triggers apoptosis via the intrinsic pathway and regulation of ROS/PI3K/Akt signalling pathway in liver carcinoma
por: Nie, Chunhui, et al.
Publicado: (2021)

Imperatorin induces autophagy and G0/G1 phase arrest via PTEN-PI3K-AKT-mTOR/p21 signaling pathway in human osteosarcoma cells in vitro and in vivo
por: Lv, Minchao, et al.
Publicado: (2021)

Overexpression of CD59 inhibits apoptosis of T-acute lymphoblastic leukemia via AKT/Notch1 signaling pathway
por: Jia, Yanfei, et al.
Publicado: (2019)

SH2B1 promotes NSCLC cell proliferation through PI3K/Akt/mTOR signaling cascade
por: Wang, Shaoqiang, et al.
Publicado: (2018)

MicroRNA-133b/EGFR axis regulates esophageal squamous cell carcinoma metastases by suppressing anoikis resistance and anchorage-independent growth
por: Zhu, Jin-Feng, et al.
Publicado: (2018)

RAC3 influences the chemoresistance of colon cancer cells through autophagy and apoptosis inhibition
por: Rubio, María Fernanda, et al.
Publicado: (2017)

Prohibitin 1 interacts with p53 in the regulation of mitochondrial dynamics and chemoresistance in gynecologic cancers
por: Kong, Bao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_s0vqdaf30pge62ml2sdbm9k2na