P11 Loss-of-Function is Associated with Decreased Cell Proliferation and Neurobehavioral Disorders in Mice

Although depression is associated with anxiety and memory deficit in humans, the molecular mechanisms of the complication remain largely unknown. In this study, we generated P11 knockout mice using CRISPR/Cas9 technology, as well as P11 knockout MEF cell lines, and confirmed depression-like phenotyp...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Guosheng, Wang, Yabo, Zheng, Weixin, Cheng, Hanhua, Zhou, Rongjia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643149/
https://www.ncbi.nlm.nih.gov/pubmed/31337969
http://dx.doi.org/10.7150/ijbs.33773

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643149/
https://www.ncbi.nlm.nih.gov/pubmed/31337969
http://dx.doi.org/10.7150/ijbs.33773

Ejemplares similares