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Specifically blocking the fatty acid synthesis to inhibit the malignant phenotype of bladder cancer
Fatty acid synthesis is regulated by transcription factors SREBPs and their escort protein SCAP. Malignant cells become dependent on de novo lipogenesis, which sustains rapid proliferation and resistance to cellular stress. Increasing evidence showed SCAP participated in various disease processes in...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643213/ https://www.ncbi.nlm.nih.gov/pubmed/31360104 http://dx.doi.org/10.7150/ijbs.32518 |