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Solution‐Based Determination of Dissociation Constants for the Binding of Aβ42 to Antibodies

Amyloid β‐peptides (Aβ) play a major role in the pathogenesis of Alzheimer's disease. Therefore, numerous monoclonal antibodies against Aβ have been developed for basic and clinical research. The present study applied fluorescence based analytical ultracentrifugation and microscale thermophores...

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Detalles Bibliográficos
Autores principales: Zhang, Tao, Nagel‐Steger, Luitgard, Willbold, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643301/
https://www.ncbi.nlm.nih.gov/pubmed/31367507
http://dx.doi.org/10.1002/open.201900167