Conservation of Potentially Druggable Cavities in Intrinsically Disordered Proteins

[Image: see text] Intrinsically disordered proteins (IDPs) exist in highly dynamic conformational ensembles, which pose a major obstacle for drug development targeting IDPs because traditional rational drug design relies on unique three-dimensional structures. Here, we analyzed the conservation (esp...

Descripción completa

Detalles Bibliográficos
Autores principales: Chong, Bin, Li, Maodong, Li, Tong, Yu, Miao, Zhang, Yugang, Liu, Zhirong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643371/
https://www.ncbi.nlm.nih.gov/pubmed/31458221
http://dx.doi.org/10.1021/acsomega.8b02092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643371/
https://www.ncbi.nlm.nih.gov/pubmed/31458221
http://dx.doi.org/10.1021/acsomega.8b02092

Ejemplares similares