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Conservation of Potentially Druggable Cavities in Intrinsically Disordered Proteins
[Image: see text] Intrinsically disordered proteins (IDPs) exist in highly dynamic conformational ensembles, which pose a major obstacle for drug development targeting IDPs because traditional rational drug design relies on unique three-dimensional structures. Here, we analyzed the conservation (esp...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643371/ https://www.ncbi.nlm.nih.gov/pubmed/31458221 http://dx.doi.org/10.1021/acsomega.8b02092 |