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A Chalcone-Based Potential Therapeutic Small Molecule That Binds to Subdomain IIA in HSA Precisely Controls the Rotamerization of Trp-214

[Image: see text] The principal intent of this work is to explore whether the site-specific binding of a newly synthesized quinoline-appended anthracenyl chalcone, (E)-3-(anthracen-10-yl)-1-(6,8-dibromo-2-methylquinolin-3-yl)prop-2-en-1-one (ADMQ), with an extracellular protein of the human circulat...

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Detalles Bibliográficos
Autores principales: Kumar, Himank, Devaraji, Vinod, Joshi, Ritika, Wankar, Sneha, Ghosh, Sujit Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644364/
https://www.ncbi.nlm.nih.gov/pubmed/31459141
http://dx.doi.org/10.1021/acsomega.8b01079