Biotransformation, Using Recombinant CYP450-Expressing Baker’s Yeast Cells, Identifies a Novel CYP2D6.10(A122V) Variant Which Is a Superior Metabolizer of Codeine to Morphine Than the Wild-Type Enzyme

[Image: see text] CYP2D6, a cytochrome P450 (CYP) enzyme, metabolizes codeine to morphine. Within the human body, 0–15% of codeine undergoes O-demethylation by CYP2D6 to form morphine, a far stronger analgesic than codeine. Genetic polymorphisms in wild-type CYP2D6 (CYP2D6-wt) are known to cause poo...

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Detalles Bibliográficos
Autores principales: Williams, Ibidapo S., Gatchie, Linda, Bharate, Sandip B., Chaudhuri, Bhabatosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644518/
https://www.ncbi.nlm.nih.gov/pubmed/31459022
http://dx.doi.org/10.1021/acsomega.8b00809

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644518/
https://www.ncbi.nlm.nih.gov/pubmed/31459022
http://dx.doi.org/10.1021/acsomega.8b00809

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