Single Amino Acid Substitution in the Vicinity of a Receptor-Binding Domain Changes Protein–Peptide Binding Affinity

[Image: see text] Using a microarray-based assay, we studied how the substitution of amino acids in the immediate vicinity of the receptor-binding domain on a peptide affects its binding to a protein. Replicates of 802 linear peptides consisting of the variants of WTHPQFAT and LQWHPQAGK, GKFPIPLGKQS...

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Detalles Bibliográficos
Autores principales: Malovichko, Galina, Zhu, Xiangdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644533/
https://www.ncbi.nlm.nih.gov/pubmed/31457812
http://dx.doi.org/10.1021/acsomega.7b00963

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644533/
https://www.ncbi.nlm.nih.gov/pubmed/31457812
http://dx.doi.org/10.1021/acsomega.7b00963

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