Cyanide-Free Ce(III)-Catalyzed Highly Efficient Synthesis of α-Iminonitriles from 2-Aminopyridines and Nitroalkenes via Intermolecular Dehydration Reaction

[Image: see text] A direct and rapid method for the synthesis of α-iminonitriles achieved good to excellent yields. A novel intermolecular dehydration reaction between 2-aminopyridines and nitroalkenes is reported via a rare-earth-metal catalyst. The merits of this transformation include cyanide-fre...

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Autores principales: Chen, Zhengwang, Liang, Pei, Zheng, Jing, Zhou, Zhonggao, Wen, Xiaowei, Liu, Tanggao, Ye, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644690/
https://www.ncbi.nlm.nih.gov/pubmed/31457985
http://dx.doi.org/10.1021/acsomega.8b02214
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author Chen, Zhengwang
Liang, Pei
Zheng, Jing
Zhou, Zhonggao
Wen, Xiaowei
Liu, Tanggao
Ye, Min
author_facet Chen, Zhengwang
Liang, Pei
Zheng, Jing
Zhou, Zhonggao
Wen, Xiaowei
Liu, Tanggao
Ye, Min
author_sort Chen, Zhengwang
collection PubMed
description [Image: see text] A direct and rapid method for the synthesis of α-iminonitriles achieved good to excellent yields. A novel intermolecular dehydration reaction between 2-aminopyridines and nitroalkenes is reported via a rare-earth-metal catalyst. The merits of this transformation include cyanide-free protocol, short reaction time, simple operation, water as the only byproduct, commercially available reagents, good functional group tolerance, etc. Moreover, nitroalkenes are demonstrated as a new “CN” source in this transformation.
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spelling pubmed-66446902019-08-27 Cyanide-Free Ce(III)-Catalyzed Highly Efficient Synthesis of α-Iminonitriles from 2-Aminopyridines and Nitroalkenes via Intermolecular Dehydration Reaction Chen, Zhengwang Liang, Pei Zheng, Jing Zhou, Zhonggao Wen, Xiaowei Liu, Tanggao Ye, Min ACS Omega [Image: see text] A direct and rapid method for the synthesis of α-iminonitriles achieved good to excellent yields. A novel intermolecular dehydration reaction between 2-aminopyridines and nitroalkenes is reported via a rare-earth-metal catalyst. The merits of this transformation include cyanide-free protocol, short reaction time, simple operation, water as the only byproduct, commercially available reagents, good functional group tolerance, etc. Moreover, nitroalkenes are demonstrated as a new “CN” source in this transformation. American Chemical Society 2018-10-03 /pmc/articles/PMC6644690/ /pubmed/31457985 http://dx.doi.org/10.1021/acsomega.8b02214 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Chen, Zhengwang
Liang, Pei
Zheng, Jing
Zhou, Zhonggao
Wen, Xiaowei
Liu, Tanggao
Ye, Min
Cyanide-Free Ce(III)-Catalyzed Highly Efficient Synthesis of α-Iminonitriles from 2-Aminopyridines and Nitroalkenes via Intermolecular Dehydration Reaction
title Cyanide-Free Ce(III)-Catalyzed Highly Efficient Synthesis of α-Iminonitriles from 2-Aminopyridines and Nitroalkenes via Intermolecular Dehydration Reaction
title_full Cyanide-Free Ce(III)-Catalyzed Highly Efficient Synthesis of α-Iminonitriles from 2-Aminopyridines and Nitroalkenes via Intermolecular Dehydration Reaction
title_fullStr Cyanide-Free Ce(III)-Catalyzed Highly Efficient Synthesis of α-Iminonitriles from 2-Aminopyridines and Nitroalkenes via Intermolecular Dehydration Reaction
title_full_unstemmed Cyanide-Free Ce(III)-Catalyzed Highly Efficient Synthesis of α-Iminonitriles from 2-Aminopyridines and Nitroalkenes via Intermolecular Dehydration Reaction
title_short Cyanide-Free Ce(III)-Catalyzed Highly Efficient Synthesis of α-Iminonitriles from 2-Aminopyridines and Nitroalkenes via Intermolecular Dehydration Reaction
title_sort cyanide-free ce(iii)-catalyzed highly efficient synthesis of α-iminonitriles from 2-aminopyridines and nitroalkenes via intermolecular dehydration reaction
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644690/
https://www.ncbi.nlm.nih.gov/pubmed/31457985
http://dx.doi.org/10.1021/acsomega.8b02214
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