Preclinical Development of Crocus sativus-Based Botanical Lead IIIM-141 for Alzheimer’s Disease: Chemical Standardization, Efficacy, Formulation Development, Pharmacokinetics, and Safety Pharmacology

[Image: see text] Crocus sativus L. (family: Iridaceae) has been documented in traditional medicine with numerous medicinal properties. Recently, we have shown that C. sativus extract (IIIM-141) displays promising efficacy in a genetic mice (5XFAD) model of Alzheimer’s disease (AD) (ACS Chem. Neuros...

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Detalles Bibliográficos
Autores principales: Bharate, Sonali S., Kumar, Vikas, Singh, Gurdarshan, Singh, Amarinder, Gupta, Mehak, Singh, Deepika, Kumar, Ajay, Vishwakarma, Ram A., Bharate, Sandip B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644748/
https://www.ncbi.nlm.nih.gov/pubmed/31459089
http://dx.doi.org/10.1021/acsomega.8b00841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644748/
https://www.ncbi.nlm.nih.gov/pubmed/31459089
http://dx.doi.org/10.1021/acsomega.8b00841

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