Phthalimide Derivatives with Bioactivity against Plasmodium falciparum: Synthesis, Evaluation, and Computational Studies Involving bc(1) Cytochrome Inhibition

[Image: see text] We describe herein the design and synthesis of N-phenyl phthalimide derivatives with inhibitory activities against Plasmodium falciparum (sensitive and resistant strains) in the low micromolar range and noticeable selectivity indices against human cells. The best inhibitor, 4-amino...

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Detalles Bibliográficos
Autores principales: Okada-Junior, Celso Yassuo, Monteiro, Gustavo Claro, Aguiar, Anna Caroline Campos, Batista, Victor Sousa, de Souza, Juliana Oliveira, Souza, Guilherme Eduardo, Bueno, Renata Vieira, Oliva, Glaucius, Nascimento-Júnior, Nailton M., Guido, Rafael Victorio Carvalho, Bolzani, Vanderlan Silva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644792/
https://www.ncbi.nlm.nih.gov/pubmed/31459076
http://dx.doi.org/10.1021/acsomega.8b01062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644792/
https://www.ncbi.nlm.nih.gov/pubmed/31459076
http://dx.doi.org/10.1021/acsomega.8b01062

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