Synthesis of 1,2,4-Trisubstituted-(1H)-imidazoles through Cu(OTf)(2)-/I(2)-Catalyzed C–C Bond Cleavage of Chalcones and Benzylamines

[Image: see text] 1,2,4-Trisubstituted-(1H)-imidazoles have been synthesized by the Cu(OTf)(2)- and I(2)-catalyzed unusual C–C bond cleavage of chalcones and benzylamines. After the α,β-unsaturated C–C bond cleavage, the β-portion is eliminated from the reaction. Various aryl- and heteroaryl-substit...

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Autores principales: Salfeena, Chettiyan Thodi F., Jalaja, Renjitha, Davis, Rincy, Suresh, Eringathodi, Somappa, Sasidhar B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644843/
https://www.ncbi.nlm.nih.gov/pubmed/31458944
http://dx.doi.org/10.1021/acsomega.8b01017
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author Salfeena, Chettiyan Thodi F.
Jalaja, Renjitha
Davis, Rincy
Suresh, Eringathodi
Somappa, Sasidhar B.
author_facet Salfeena, Chettiyan Thodi F.
Jalaja, Renjitha
Davis, Rincy
Suresh, Eringathodi
Somappa, Sasidhar B.
author_sort Salfeena, Chettiyan Thodi F.
collection PubMed
description [Image: see text] 1,2,4-Trisubstituted-(1H)-imidazoles have been synthesized by the Cu(OTf)(2)- and I(2)-catalyzed unusual C–C bond cleavage of chalcones and benzylamines. After the α,β-unsaturated C–C bond cleavage, the β-portion is eliminated from the reaction. Various aryl- and heteroaryl-substituted chalcones and benzylamines were well tolerated in this unusual transformation to yield the trisubstituted-(1H)-imidazoles.
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spelling pubmed-66448432019-08-27 Synthesis of 1,2,4-Trisubstituted-(1H)-imidazoles through Cu(OTf)(2)-/I(2)-Catalyzed C–C Bond Cleavage of Chalcones and Benzylamines Salfeena, Chettiyan Thodi F. Jalaja, Renjitha Davis, Rincy Suresh, Eringathodi Somappa, Sasidhar B. ACS Omega [Image: see text] 1,2,4-Trisubstituted-(1H)-imidazoles have been synthesized by the Cu(OTf)(2)- and I(2)-catalyzed unusual C–C bond cleavage of chalcones and benzylamines. After the α,β-unsaturated C–C bond cleavage, the β-portion is eliminated from the reaction. Various aryl- and heteroaryl-substituted chalcones and benzylamines were well tolerated in this unusual transformation to yield the trisubstituted-(1H)-imidazoles. American Chemical Society 2018-07-19 /pmc/articles/PMC6644843/ /pubmed/31458944 http://dx.doi.org/10.1021/acsomega.8b01017 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Salfeena, Chettiyan Thodi F.
Jalaja, Renjitha
Davis, Rincy
Suresh, Eringathodi
Somappa, Sasidhar B.
Synthesis of 1,2,4-Trisubstituted-(1H)-imidazoles through Cu(OTf)(2)-/I(2)-Catalyzed C–C Bond Cleavage of Chalcones and Benzylamines
title Synthesis of 1,2,4-Trisubstituted-(1H)-imidazoles through Cu(OTf)(2)-/I(2)-Catalyzed C–C Bond Cleavage of Chalcones and Benzylamines
title_full Synthesis of 1,2,4-Trisubstituted-(1H)-imidazoles through Cu(OTf)(2)-/I(2)-Catalyzed C–C Bond Cleavage of Chalcones and Benzylamines
title_fullStr Synthesis of 1,2,4-Trisubstituted-(1H)-imidazoles through Cu(OTf)(2)-/I(2)-Catalyzed C–C Bond Cleavage of Chalcones and Benzylamines
title_full_unstemmed Synthesis of 1,2,4-Trisubstituted-(1H)-imidazoles through Cu(OTf)(2)-/I(2)-Catalyzed C–C Bond Cleavage of Chalcones and Benzylamines
title_short Synthesis of 1,2,4-Trisubstituted-(1H)-imidazoles through Cu(OTf)(2)-/I(2)-Catalyzed C–C Bond Cleavage of Chalcones and Benzylamines
title_sort synthesis of 1,2,4-trisubstituted-(1h)-imidazoles through cu(otf)(2)-/i(2)-catalyzed c–c bond cleavage of chalcones and benzylamines
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644843/
https://www.ncbi.nlm.nih.gov/pubmed/31458944
http://dx.doi.org/10.1021/acsomega.8b01017
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