Synthetic Studies toward the Natural Product Tripartin, the First Natural Histone Lysine Demethylase Inhibitor

[Image: see text] An efficient synthesis of dimethyl tripartin as a synthetic precursor of natural product tripartin, the first natural specific inhibitor of histone H3 lysine 9 demethylase KDM4, is described. The synthesis of dimethyl tripartin was achieved in a six-step longest linear sequence sta...

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Autores principales: Dethe, Dattatraya H., Boda, Raghavender
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6645238/
https://www.ncbi.nlm.nih.gov/pubmed/31459063
http://dx.doi.org/10.1021/acsomega.8b01341
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author Dethe, Dattatraya H.
Boda, Raghavender
author_facet Dethe, Dattatraya H.
Boda, Raghavender
author_sort Dethe, Dattatraya H.
collection PubMed
description [Image: see text] An efficient synthesis of dimethyl tripartin as a synthetic precursor of natural product tripartin, the first natural specific inhibitor of histone H3 lysine 9 demethylase KDM4, is described. The synthesis of dimethyl tripartin was achieved in a six-step longest linear sequence starting from commercially available 3,5-dimethoxy benzaldehyde with 21% overall yield, using ClTi(O(i)Pr)(3)-mediated dichloromethine insertion as the key step.
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spelling pubmed-66452382019-08-27 Synthetic Studies toward the Natural Product Tripartin, the First Natural Histone Lysine Demethylase Inhibitor Dethe, Dattatraya H. Boda, Raghavender ACS Omega [Image: see text] An efficient synthesis of dimethyl tripartin as a synthetic precursor of natural product tripartin, the first natural specific inhibitor of histone H3 lysine 9 demethylase KDM4, is described. The synthesis of dimethyl tripartin was achieved in a six-step longest linear sequence starting from commercially available 3,5-dimethoxy benzaldehyde with 21% overall yield, using ClTi(O(i)Pr)(3)-mediated dichloromethine insertion as the key step. American Chemical Society 2018-08-16 /pmc/articles/PMC6645238/ /pubmed/31459063 http://dx.doi.org/10.1021/acsomega.8b01341 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Dethe, Dattatraya H.
Boda, Raghavender
Synthetic Studies toward the Natural Product Tripartin, the First Natural Histone Lysine Demethylase Inhibitor
title Synthetic Studies toward the Natural Product Tripartin, the First Natural Histone Lysine Demethylase Inhibitor
title_full Synthetic Studies toward the Natural Product Tripartin, the First Natural Histone Lysine Demethylase Inhibitor
title_fullStr Synthetic Studies toward the Natural Product Tripartin, the First Natural Histone Lysine Demethylase Inhibitor
title_full_unstemmed Synthetic Studies toward the Natural Product Tripartin, the First Natural Histone Lysine Demethylase Inhibitor
title_short Synthetic Studies toward the Natural Product Tripartin, the First Natural Histone Lysine Demethylase Inhibitor
title_sort synthetic studies toward the natural product tripartin, the first natural histone lysine demethylase inhibitor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6645238/
https://www.ncbi.nlm.nih.gov/pubmed/31459063
http://dx.doi.org/10.1021/acsomega.8b01341
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