Cargando…

Oridonin overcomes the gemcitabine resistant PANC-1/Gem cells by regulating GST pi and LRP/1 ERK/JNK signalling

Background: Chemotherapy remains a primary treatment method for advanced pancreatic cancer. However, chemotherapy resistance can influence the therapeutic effect of pancreatic cancer. The resistance mechanism of chemotherapeutic agents such as gemcitabine, which is an agent typically used to treat p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Bili, Shen, Can, Li, Yang, Zhang, Ting, Huang, Hui, Ren, Jun, Hu, Zhengjun, Xu, Jian, Xu, Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6645696/ https://www.ncbi.nlm.nih.gov/pubmed/31410021 http://dx.doi.org/10.2147/OTT.S208924

Ejemplares similares

Gemcitabine-loaded albumin nanospheres (GEM-ANPs) inhibit PANC-1 cells in vitro and in vivo
por: Li, Ji, et al.
Publicado: (2013)

Biodegradable Polymersomes for the Delivery of Gemcitabine to Panc-1 Cells
por: Sood, Nimil, et al.
Publicado: (2013)

Oridonin nanosuspension was more effective than free oridonin on G(2)/M cell cycle arrest and apoptosis in the human pancreatic cancer PANC-1 cell line
por: Qi, Xiaoli, et al.
Publicado: (2012)

LRP-1 Promotes Cancer Cell Invasion by Supporting ERK and Inhibiting JNK Signaling Pathways
por: Langlois, Benoit, et al.
Publicado: (2010)

Oridonin and its derivatives for cancer treatment and overcoming therapeutic resistance
por: Liu, Xi, et al.
Publicado: (2020)

Depletion of pro-oncogenic RUNX2 enhances gemcitabine (GEM) sensitivity of p53-mutated pancreatic cancer Panc-1 cells through the induction of pro-apoptotic TAp63
por: Ozaki, Toshinori, et al.
Publicado: (2016)

Synergistic effect of the herbal mixture C5E on gemcitabine treatment in PANC-1 cells
por: Pak, Pyo June, et al.
Publicado: (2021)

Oridonin induces apoptosis in HGC-27 cells by activating the JNK signaling pathway
por: Ren, Dong-Lin, et al.
Publicado: (2020)

Cancer Stem-Like Cells Enriched in Panc-1 Spheres Possess Increased Migration Ability and Resistance to Gemcitabine
por: Yin, Tao, et al.
Publicado: (2011)

LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways
por: Yang, Longyu, et al.
Publicado: (2016)

HMGB1-mediated autophagy attenuates gemcitabine-induced apoptosis in bladder cancer cells involving JNK and ERK activation
por: Yin, Hubin, et al.
Publicado: (2017)

Differential Roles for VviGST1, VviGST3, and VviGST4 in Proanthocyanidin and Anthocyanin Transport in Vitis vinífera
por: Pérez-Díaz, Ricardo, et al.
Publicado: (2016)

Effect of quercetin on apoptosis of PANC-1 cells
por: Lee, Joo Hyun, et al.
Publicado: (2013)

Oridonin inhibits the migration and epithelial‐to‐mesenchymal transition of small cell lung cancer cells by suppressing FAK‐ERK1/2 signalling pathway
por: Xu, Linhao, et al.
Publicado: (2020)

LRP1 as a promising therapeutic target for gastrointestinal tumors: Inhibiting proliferation, invasion and migration of cancer cells
por: Zhu, Mengying, et al.
Publicado: (2023)

JWA gene regulates PANC-1 pancreatic cancer cell behaviors through MEK-ERK1/2 of the MAPK signaling pathway
por: WU, YUAN-YUAN, et al.
Publicado: (2014)

Synergistic suppression of t(8;21)-positive leukemia cell growth by combining oridonin and MAPK1/ERK2 inhibitors
por: Spirin, Pavel, et al.
Publicado: (2017)

Downregulation of miR-183 inhibits the growth of PANC-1 pancreatic cancer cells in vitro and in vivo, and increases chemosensitivity to 5-fluorouracil and gemcitabine
por: Yang, Xiaoping, et al.
Publicado: (2019)

Multidrug resistance protein 5 affects cell proliferation, migration and gemcitabine sensitivity in pancreatic cancer MIA Paca‑2 and PANC‑1 cells
por: He, Ji, et al.
Publicado: (2023)

Oridonin enhances the anti-tumor activity of gemcitabine towards pancreatic cancer by stimulating Bax- and Smac-dependent apoptosis
por: Liu, Dian-Lei, et al.
Publicado: (2020)

Antiangiogenic effects of oridonin
por: Tian, Lili, et al.
Publicado: (2017)

JNK, p38, ERK, and SGK1 Inhibitors in Cancer
por: Cicenas, Jonas, et al.
Publicado: (2017)

Molecular Cloning and Expression of MnGST-1 and MnGST-2 from Oriental River Prawn, Macrobrachium nipponense, in Response to Hypoxia and Reoxygenation
por: Xu, Lei, et al.
Publicado: (2018)

Expression of mdr1 and gst-pi in human breast tumours: comparison to in vitro chemosensitivity.
por: Keith, W. N., et al.
Publicado: (1990)

Impact of GST thickness on GST-loaded silicon waveguides for optimal optical switching
por: Parra, Jorge, et al.
Publicado: (2022)

Gemcitabine plus capecitabine (Gem–Cape) biweekly in chemorefractory metastatic colorectal cancer
por: Jiménez-Fonseca, P., et al.
Publicado: (2014)

Is gemcitabine (GEM)-based combination therapy good for the treatment of advanced pancreatic cancer?
por: Hao, Fulong, et al.
Publicado: (2023)

Emerging Contribution of PancRNAs in Cancer
por: Mercatelli, Neri, et al.
Publicado: (2020)

Glycolysis in Panc-1 human pancreatic cancer cells is inhibited by everolimus
por: LIU, LING, et al.
Publicado: (2013)

MicroRNAs Targeting Caspase-3 and -7 in PANC-1 Cells
por: Park, Jong Kook, et al.
Publicado: (2018)

CAFs/tumor cells co-targeting DNA vaccine in combination with low-dose gemcitabine for the treatment of Panc02 murine pancreatic cancer
por: Geng, Fei, et al.
Publicado: (2022)

Combination L-Glutamine with Gemcitabine and Nab-Paclitaxel in Treatment-Naïve Advanced Pancreatic Cancer: The Phase I GlutaPanc Study Protocol
por: Gong, Jun, et al.
Publicado: (2023)

Glutathione-S-transferase-pi (GST-pi) expression in renal cell carcinoma
por: Kaprilian, Christina, et al.
Publicado: (2015)

Metformin Inhibits Proliferation of Human Thyroid Cancer TPC-1 Cells by Decreasing LRP2 to Suppress the JNK Pathway
por: He, Yang, et al.
Publicado: (2020)

Berberine Overcomes Gemcitabine-Associated Chemoresistance through Regulation of Rap1/PI3K-Akt Signaling in Pancreatic Ductal Adenocarcinoma
por: Okuno, Keisuke, et al.
Publicado: (2022)

X-ray structures of Na-GST-1 and Na-GST-2 two glutathione s-transferase from the human hookworm Necator americanus
por: Asojo, Oluwatoyin A, et al.
Publicado: (2007)

Expression of MTA1 promotes motility and invasiveness of PANC-1 pancreatic carcinoma cells
por: Hofer, M D, et al.
Publicado: (2004)

Oridonin, a Promising ent-Kaurane Diterpenoid Lead Compound
por: Li, Dahong, et al.
Publicado: (2016)

Erratum to: Gemcitabine plus capecitabine (Gem–Cape) biweekly in chemorefractory metastatic colorectal cancer
por: Jiménez-Fonseca, P., et al.
Publicado: (2014)

Antiviral Activity of Oridonin Against Herpes Simplex Virus Type 1
por: Jiang, Kai, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vufscs9eafrag99gn2047hthbi