Calreticulin Ins5 and Del52 mutations impair unfolded protein and oxidative stress responses in K562 cells expressing CALR mutants

Somatic mutations of calreticulin (CALR) have been described in approximately 60–80% of JAK2 and MPL unmutated Essential Thrombocythemia and Primary Myelofibrosis patients. CALR is an endoplasmic reticulum (ER) chaperone responsible for proper protein folding and calcium retention. Recent data demon...

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Detalles Bibliográficos
Autores principales: Salati, Simona, Genovese, Elena, Carretta, Chiara, Zini, Roberta, Bartalucci, Niccolò, Prudente, Zelia, Pennucci, Valentina, Ruberti, Samantha, Rossi, Chiara, Rontauroli, Sebastiano, Enzo, Elena, Calabresi, Laura, Balliu, Manjola, Mannarelli, Carmela, Bianchi, Elisa, Guglielmelli, Paola, Tagliafico, Enrico, Vannucchi, Alessandro M., Manfredini, Rossella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646313/
https://www.ncbi.nlm.nih.gov/pubmed/31332222
http://dx.doi.org/10.1038/s41598-019-46843-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646313/
https://www.ncbi.nlm.nih.gov/pubmed/31332222
http://dx.doi.org/10.1038/s41598-019-46843-z

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