Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics

Teixobactin represents a new class of antibiotics with novel structure and excellent activity against Gram-positive pathogens and Mycobacterium tuberculosis. Herein, we report a one-pot reaction to conveniently construct the key building block l-allo-Enduracidine in 30-gram scale in just one hour  a...

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Detalles Bibliográficos
Autores principales: Zong, Yu, Fang, Fang, Meyer, Kirsten J., Wang, Liguo, Ni, Zhihao, Gao, Hongying, Lewis, Kim, Zhang, Jingren, Rao, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646333/
https://www.ncbi.nlm.nih.gov/pubmed/31332172
http://dx.doi.org/10.1038/s41467-019-11211-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646333/
https://www.ncbi.nlm.nih.gov/pubmed/31332172
http://dx.doi.org/10.1038/s41467-019-11211-y

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