mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy

Down syndrome (DS), a complex genetic disorder caused by chromosome 21 trisomy, is associated with mitochondrial dysfunction leading to the accumulation of damaged mitochondria. Here we report that mitophagy, a form of selective autophagy activated to clear damaged mitochondria is deficient in prima...

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Detalles Bibliográficos
Autores principales: Bordi, Matteo, Darji, Sandipkumar, Sato, Yutaka, Mellén, Marian, Berg, Martin J., Kumar, Asok, Jiang, Ying, Nixon, Ralph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646359/
https://www.ncbi.nlm.nih.gov/pubmed/31332166
http://dx.doi.org/10.1038/s41419-019-1752-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646359/
https://www.ncbi.nlm.nih.gov/pubmed/31332166
http://dx.doi.org/10.1038/s41419-019-1752-5

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