An oligo-His-tag of a targeting module does not influence its biodistribution and the retargeting capabilities of UniCAR T cells

Recently, we established the controllable modular UniCAR platform technology to advance the efficacy and safety of CAR T cell therapy. The UniCAR system is composed of (i) target modules (TMs) and (ii) UniCAR armed T cells. TMs are bispecific molecules that are able to bind to the tumor cell surface...

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Detalles Bibliográficos
Autores principales: Jureczek, Justyna, Bergmann, Ralf, Berndt, Nicole, Koristka, Stefanie, Kegler, Alexandra, Puentes-Cala, Edinson, Soto, Javier Andrés, Arndt, Claudia, Bachmann, Michael, Feldmann, Anja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646371/
https://www.ncbi.nlm.nih.gov/pubmed/31332252
http://dx.doi.org/10.1038/s41598-019-47044-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646371/
https://www.ncbi.nlm.nih.gov/pubmed/31332252
http://dx.doi.org/10.1038/s41598-019-47044-4

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