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Neuronal Circuit-Based Computer Modeling as a Phenotypic Strategy for CNS R&D
With the success rate of drugs for CNS indications at an all-time low, new approaches are needed to turn the tide of failed clinical trials. This paper reviews the history of CNS drug Discovery over the last 60 years and proposes a new paradigm based on the lessons learned. The initial wave of succe...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646593/ https://www.ncbi.nlm.nih.gov/pubmed/31379482 http://dx.doi.org/10.3389/fnins.2019.00723 |