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Reprogramming the Epigenome With Vitamin C

The erasure of epigenetic modifications across the genome of somatic cells is an essential requirement during their reprogramming into induced pluripotent stem cells (iPSCs). Vitamin C plays a pivotal role in remodeling the epigenome by enhancing the activity of Jumonji-C domain-containing histone d...

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Detalles Bibliográficos
Autores principales: Lee Chong, Taylor, Ahearn, Emily L., Cimmino, Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646595/
https://www.ncbi.nlm.nih.gov/pubmed/31380368
http://dx.doi.org/10.3389/fcell.2019.00128